In Night of MayhemYou will become a tower defense commander, fighting against waves of mindless cyborg drones. You will have 3 different characters to choose from, each belonging to a separate faction, using different weapons and elements to fight different types of threats.

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The three main elements in the game are Redinium, Nanopulse and Snythogen. Each element has its own strengths and weaknesses, so you need to use them strategically to destroy your enemies. You can also rotate the platform around to face different types of enemies.